Conductance of GABA A Channels Activated by Pentobarbitone in Hippocampal Neurons from Newborn Rats
نویسندگان
چکیده
منابع مشابه
Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA.
In the hippocampus, two distinct forms of GABAergic inhibition have been identified, phasic inhibitory postsynaptic currents that are the consequence of the vesicular release of GABA and a tonic conductance that is activated by low ambient concentrations of extracellular GABA. It is not known what accounts for the distinct properties of receptors that mediate the phasic and tonic inhibitory con...
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De Koninck, Yves and Istvan Mody. Endogenous GABA actition of these receptors to raise the intracellular concentration vates small-conductance K channels underlying slow IPSCs in of G proteins to the level required for activation of the K rat hippocampal neurons. J. Neurophysiol. 77: 2202–2208, 1997. channels (Destexhe and Sejnowski 1995), or 3) cause the The objective of this study was to dete...
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The objective of this study was to determine the properties of K+ channels activated by endogenously released trasmitter under synaptic conditions. First, the levels of gamma-aminobutyric acid (GABA) were depleted in hippocampal nerve endings to establish the relative contribution of endogenously released GABA to the activation of GABA(B) receptors mediating slow inhibitory postsynaptic current...
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With the use of a whole cell voltage-clamp technique and fura-2 fluorescence measurements, the actions of gamma-aminobutyric acid (GABA) on cultured neurons from rat inferior colliculus were investigated. GABA (10-1,000 microM) induced currents in neurons held under voltage clamp that were inhibited by bicuculline (20 microM). Muscimol (100 microM) also evoked the currents, whereas baclofen (10...
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The physiological properties of hippocampal neurons are commonly investigated, especially because of the involvement of the hippocampus in learning and memory. Primary hippocampal cell culturing allows neuroscientists to examine the activity and properties of neurons at the individual cell and single synapse level. In this video, we will demonstrate how to isolate and grow primary hippocampal c...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2003
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2003.047415